A summary from: Health Benefits of Dietary Nucleotides, by Mathew Eng
Nucleotides are organic compounds that are essential in all living organisms. They act as building blocks for DNA and RNA, which contain all our genetic information.
Nucleotides also play a critical role in metabolism and energy. They transport energy in the form of ATP to power different parts of the cell. This energy is used to create new proteins, cells, and other vital components.
The primary source is from our own bodies. The human body naturally produces nucleotides by either creating them from scratch or salvaging parts from cells.
Nucleotides are naturally found in meats, fruits, and vegetables. Foods that have high cell density (organ meats, fish, and seeds) contain the highest nucleotide levels.
Some scientists hypothesize that areas in the body that experience a high turnover of cells may benefit the most from nucleotides. Cells in the immune system, liver, and gut tend to have very short lives and new cells must be constantly made. This results in a high demand for nucleotides in these areas of the body, at least in animal experiments.
(Although) human data is lacking, (We are personally rapidly acquiring amazing yet anecdotal testimonials from people being transformed by using good nucleotide supplementation.)
Digestive System Health
The cells in our gut need to be constantly renewed. Several animal studies suggest that nucleotide supplementation may assist with this cell rebuilding .
Our intestines have special structures called villi that help absorb nutrients. Research shows that nucleotides might promote villi growth, potentially improving nutrient absorption. In one study, rats that were given nucleotide precursors had 25% larger villi [27, 28].
Nucleotide-supplemented diets are also being researched for helping repair the gut after injury. Based on rat studies, they might help recover the damage caused by malnutrition, organ transplant, and chronic diarrhea.
Nucleotides provide essential components that the body needs to build new cells. It may come as no surprise that nucleotides are being researched for promoting growth as well.
Studies suggest that nucleotides can increase growth in rats, fish, and sea cucumbers. All of these animals had better growth and weight gain when supplements were added to their diet. Human studies have yet to be carried out.
Lab rats live longer when their diets are supplemented with nucleotides. A study suggested that dietary nucleotides may increase the average lifespan of rats and decrease tumor-related deaths.
Memory and Learning
The brain is another area in the body that requires a healthy supply of nucleotides. Based on one study, dietary nucleotides may help the brain by improving memory. Old and young mice perform better on memory tests when they are given nucleotide supplements .
In addition, rats on a nucleotide-supplemented diet were better at learning tasks. The researchers found that these rats metabolize fat in the brain differently.
Users of nucleotide supplements tend to leave positive reviews. Many claim they receive an energy boost. They also appear to be popular for their immune system benefits. Some users like to take nucleotides at the first sign of a cold or flu to prevent infections.
Negative reviews primarily come from users who saw no results when taking nucleotide supplements.
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