The Best Version of Yourself

SUCCESS will occur in any person’s life when Opportunity and Preparedness meet. It is one of the most important focal points in any one’s life.  The Avini Opportunity places YOU in the right place at the right time.  And when you choose to build a business team through sharing Avini Health, you are dealing with many reassuring certainties. Our biochemist has a 25+ year track of doing billions of dollars in sales of these very products.  During his lifetime, our CEO has led traditional billion-dollar corporate America businesses as well as being a top field leader in MLM.  We have attracted many top-tier field leaders. Everyone who is involved in all the key positions of Avini is experienced.  This is not our first rodeo!  We’ve done it before and now we’re doing it again.  Avini Health is truly a ground-floor opportunity with huge growth potential, and yet we have the look and feel of an established several year old, expertly run, and debt free business. The story of our company and products is unique and fun to share.

When I reflect on my almost 47 years of MLM experience, I would say the essentials for success are having an exciting product to represent, passionate and visionary leadership along with competent business knowledge and trustworthiness. I have often been disappointed by giving my heart to a company that lacked good business acumen or trust. Trust truly is the one thing that changes everything. I am super excited to say that I have found Avini Health to be the company that has my favorite products and led by people with fantastic business smarts who are trustworthy.  Today Avini Health is my finest career!

There comes a special moment in everyone’s life, a moment for which that person was born. That special opportunity, when he seizes it, will fulfill his mission – a mission for which he is uniquely qualified. In that moment, he will find greatness. It is his finest hour… Unfortunately most people just pick themselves up, dust themselves down, and walk away from it.   – Churchill

Network marketing done right is business in its finest form.  It’s people helping people.  Are you the right person?  You can be!  John Maxwell says that “Almost everything we become and accomplish in life is with and through people.  Therefore, the ability to connect and create relationships with others is the most important skill that we can learn.”

I believe that all of these factors make Avini the greatest pathway to becoming the best version of yourself.  This is truly a personal development program as well as a great business. This is the right place and time for you to enjoy a meaningful opportunity.

From one who believes in you!

Dave Johnson

Check all the great resources on Rich Kotter’s site.

Everything you ever wanted to know about the p53 tumor suppression gene but were afraid to ask!

Tumor Suppression: Targeting p53 pathways: mechanisms, structures, and advances in therapy, notes taken from an abstract,

The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has been a major focus of oncology research…

(it) plays critical roles in regulating cell cycle, apoptosis, and genomic stability, and is widely regarded as the “guardian of the genome”.

p53 also regulates cell metabolism, ferroptosis, tumor microenvironment, autophagy and so on, all of which contribute to tumor suppression. Mutations in TP53 not only impair its tumor suppressor function, but also confer oncogenic properties to p53 mutants.  (Tending to cause or give rise to tumors)

An oncogene is a gene that has the potential to cause cancer.[1] In tumor cells, these genes are often mutated, or expressed at high levels.[2]

Most normal cells will undergo a programmed form of rapid cell death (apoptosis) when critical functions are altered and malfunction. Activated oncogenes can cause those cells designated for apoptosis to survive and proliferate instead.[3

Usually, multiple oncogenes, along with mutated apoptotic or tumor suppressor genes, will all act in concert to cause cancer.

The biological function of p53 in cancer

p53 controls a wide range of signaling networks. There is no simple and clear answer to the question of exactly how, when, and what p53 does. Nevertheless, what is clear is that p53 has a very flexible and versatile response, with an integrated response to environmental perturbations determining cell death or maintaining cellular homeostasis. p53 serves as a linkage point for multiple cellular signaling pathways, harmoniously and delicately regulating various biological functions through transcriptional regulation and protein-protein interactions.

p53 is considered as the guardian of the genome. It plays an important role in maintaining genomic stability. When DNA is damaged, p53 protects the genome by coordinating multiple DNA damage response mechanisms.51 The p53 protein activates the expression of DNA repair proteins DDB2 and XPC.52 The interaction of these proteins with effector proteins may lead to various cell fates, such as apoptosis, senescence or tumorigenesis.53,54

Metabolic homeostasis

Tumor cells require large amounts of biological raw materials and energy to achieve their rapid and sustained growth. The Warburg effect,90 which was first proposed, states that tumor cells metabolize glucose differently than normal cells, as evidenced by enhanced glycolysis and increased lactate production.91 p53 regulation of the glycolytic pathway helps maintain the homeostasis of cellular metabolism and thus acts as a tumor suppressor.

This is a youtube about what this is doing for animals

An interview with the biochemist who created it  :